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lst1 = [1, 2, 3] lst2 = [2, 5, 3, 9] combine = [(a, b) for a in lst1 for b in lst2 if a != b] print(combine) ''' run: [(1, 2), (1, 5), (1, 3), (1, 9), (2, 5), (2, 3), (2, 9), (3, 2), (3, 5), (3, 9)] '''